Journal article
Evaluation of Potential DnaK Modulating Proline-Rich Antimicrobial Peptides Identified by Computational Screening
TNG Handley, W Li, NG Welch, NM O’Brien-Simpson, MA Hossain, JD Wade
Frontiers in Chemistry | FRONTIERS MEDIA SA | Published : 2022
Abstract
The day is rapidly approaching where current antibiotic therapies will no longer be effective due to the development of multi-drug resistant bacteria. Antimicrobial peptides (AMPs) are a promising class of therapeutic agents which have the potential to help address this burgeoning problem. Proline-rich AMPs (PrAMPs) are a sub-class of AMPs, that have multiple modes of action including modulation of the bacterial protein folding chaperone, DnaK. They are highly effective against Gram-negative bacteria and have low toxicity to mammalian cells. Previously we used an in silico approach to identify new potential PrAMPs from the DRAMP database. Four of these peptides, antibacterial napin, attacin-..
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Awarded by University of Melbourne
Funding Acknowledgements
NO-S was the recipient of NHMRC funding (APP1142472, Q10 APP1158841, APP1185426), ARC funding (DP160101312, LE200100163), Cancer Council Victoria funding (APP1163284), and Australian Dental Research. Funding in antimicrobial materials and research is supported by the Centre for Oral Health Research in the Basic and Clinical Oral Sciences Division at The Melbourne Dental School. JW was an NHMRC Principal Research Fellow (1117483). The studies undertaken in his laboratory were supported by an NHMRC Project grant (APP1158841). WL was the recipient of the 2019 Weary Dunlop Foundation grant and 2020 Early Career Researcher grant scheme of the University of Melbourne. Research at The Florey Institute of Neuroscience and Mental Health was supported by the Victorian Government Operational Infrastructure Support Program.